Utility of colon leakage score in left-sided colorectal surgery

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• 作者：Xue-Qiao Yu ; PhD^a ; ^{yuxueqiao2008@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{yuxueqiao2009@163.com" class="auth_mail" title="E-mail the corresponding author} ; Bo Zhao ; PhD^b ; Wei-Ping Zhou ; BS^c ; Li-Zhen Han ; MS^d ; Guo-Hao Cai ; BS^c ; Zhuang-Wei Fang ; MS^c ; Yong-Hong Peng​ ; MS^c ; Bo Yuan ; MS^c
• 关键词：Colon cancer ; Left-sided colorectal surgery ; Anastomotic leakage ; Risk ; Colon leakage score
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：15 May 2016
• 年：2016
• 卷：202
• 期：2
• 页码：398-402
• 全文大小：269 K

文摘

The aim of the study was to evaluate the clinical utility of the colon leakage score (CLS) in predicting the risk of anastomotic leakage (AL) after left-sided colorectal surgery.

Materials and methods

This investigation was designed as a retrospective study of 304 patients who underwent left-sided colorectal surgery. The patients were classified into two groups as those who developed AL and those who did not develop AL, and the CLSs of the two groups were compared. The predictive value and the cutoff value of the CLS were assessed by receiver operating characteristic and logistic regression analysis.

Results

A significant difference was noted in the mean CLSs of the groups with and without AL (P < 0.001). The values of the area under the receiver operating characteristic curve (0.965; confidence interval, 0.913–1.00) and the odds ratio (2.9; confidence interval, 1.59–4.83; P < 0.001) indicated that CLS was a good predictor of AL. A CLS of 11 was found to be the best cutoff value, with a sensitivity and specificity of 84.6% and 87.2%, respectively.

Conclusions

Our findings indicate that CLS can effectively predict the risk of AL after left-sided colorectal surgery and that a CLS of 11 can be used as a cutoff value for the risk level.