SF-1 overexpression in childhood adrenocortical tumours

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• 作者：Mara A.D. Pianovski ; Luciane R. Cavalli ; Bonald C. Figueiredo ; Savana C.L. Santos ; Mabrouka Doghman ; Raul C. Ribeiro ; Antonio G. Oliveira ; Edson Michalkiewicz ; Giovanna A. Rodrigues ; Gerard Zambetti <
• 关键词：FISH ; Steroidogenic factor 1 (SF-1) ; Adrenal cortex ; Childhood tumours
• 刊名：European Journal of Cancer
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：42
• 期：8
• 页码：1040-1043
• 全文大小：145 K

文摘

The steroidogenic factor 1 (SF-1) gene encodes a transcription factor playing a pivotal role in the regulation of adrenogenital development. We have recently shown that SF-1 is amplified in childhood adrenocortical tumours (ACT). This study was aimed to assess if an increase in SF-1 gene copy number was associated with increased protein levels and to study the correlation between SF-1 expression and ACT clinical parameters. An increased SF-1 copy number was detected in eight of the 10 ACT cases studied. Conversely, the SF-1 protein was found to be overexpressed in all cases, compared to normal age-matched adrenal glands. No significant correlation was found between SF-1 protein levels and its gene copy number. Furthermore, no significant correlation existed with histological grade or with the clinical manifestation or evolution of disease. This data show that SF-1 overexpression is widespread in childhood ACT and is likely to play a role in its pathogenesis.