Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial

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• 作者：Nicholas J. Vogelzang<sup>1sup><sup> ; sup><sup>Nicholas.Vogelzang@USOncology.comsup> ; Robert E. Coleman<sup>2sup> ; Jeff M. Michalski<sup>3sup> ; Sten Nilsson<sup>4sup> ; Joe M. O'Sullivan<sup>5sup> ; Christopher Parker<sup>6sup> ; Anders Widmark<sup>7sup> ; Marcus Thuresson<sup>8sup> ; Lei Xu<sup>9sup> ; Joseph Germino<sup>10sup> ; Oliver Sartor<sup>11sup>
• 关键词：Alpha-emitting radiopharmaceutical ; Anemia ; Castration-resistant prostate cancer ; Myelotoxicity ; Thrombocytopenia
• 刊名：Clinical Genitourinary Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：1
• 页码：42-52.e8
• 全文大小：690 K
• 卷排序：15

文摘

Myelosuppression is common in patients with progressive castration-resistant prostate cancer and bone metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; understanding risk factors will improve clinical decision making. We describe hematologic safety of radium-223 in ALSYMPCA and post hoc analyses identifying patients at increased risk for hematologic toxicity.Patients and MethodsHematologic parameters and adverse events were analyzed. Multivariate analyses assessing baseline risk factors for hematologic toxicities were performed separately for radium-223 and placebo patients.ResultsNine hundred one patients received radium-223 (n = 600) or placebo (n = 301); 65% of radium-223 and 48% of placebo patients had the full 6 cycles. Grade 3/4 thrombocytopenia was more common in radium-223 versus placebo patients (6% vs. 2%). Logistic regression analyses identified significant baseline predictors for grade 2-4 hematologic toxicities related to radium-223 treatment: extent of disease (6-20 vs. &lt; 6 bone metastases; odds ratio [OR] = 2.76; P = .022) and elevated prostate-specific antigen (OR = 1.65; P = .006) for anemia; prior docetaxel (OR = 2.16; P = .035), decreased hemoglobin (OR = 1.35; P = .008), and decreased platelets (OR = 1.44; P = .030) for thrombocytopenia. Neutropenia events were too few in placebo patients for a comparative analysis. There were no significant associations between hematologic toxicities and number of radium-223 injections received (4-6 vs. 1-3).ConclusionRadium-223 has a favorable safety profile with a low myelosuppression incidence. Understanding baseline factors associated with myelosuppression may assist clinicians in avoiding severe myelosuppression events with radium-223.