The genotoxic potency of glycidol established from micronucleus frequency and hemoglobin adduct levels in mice

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• 作者：Jenny Aasa^a ; Lilianne Abramsson-Zetterberg^b ; ^{lilianne.abramsson@slv.se} ; Henrik Carlsson^a ; Margareta Tö ; rnqvist^a ; ^{margareta.tornqvist@aces.su.se}
• 关键词：Glycidol ; Micronucleus ; Hb adducts ; Genotoxicity ; In vivo ; Mice
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：168-174
• 全文大小：487 K
• 卷排序：100

文摘

The genotoxic potency of glycidol was quantified in mice, from induction of micronuclei and hemoglobin adducts. A more exact dose-response relationship was established compared to calculations based on administered dose. Comparing glycidol to ionizing radiation gives a relative genotoxic potency of 16 rad-eq. per mMh of glycidol. Glycidol has a lower potency for induction of micronuclei than other studied simple alkyl epoxides. This study approach is attractive from a 3R principles perspective.