Efficacy of triclosan-coated sutures for reducing risk of surgical site infection in adults: a meta-analysis of randomized clinical trials

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• 作者：Jiao Guo ; MD^a ; ¹ ; Ling-Hui Pan ; MD ; PhD^b ; ¹ ; Yun-Xi Li ; MD^c ; ¹ ; Xiang-Di Yang ; MD^a ; Le-Qun Li ; MD ; PhD^d ; Chun-Yan Zhang ; MD^a ; ^{zcy_263@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jian-Hong Zhong ; MD^d ; ^{zhongjianhong66@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Surgical site infection ; Triclosan ; Suture ; Antimicrobial ; Antiseptic
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：201
• 期：1
• 页码：105-117
• 全文大小：1624 K

文摘

Surgical site infection (SSI) is the third most frequent type of nosocomial infections. Triclosan-coated sutures are often used to reduce the risk of SSI, but studies examining this have given conflicting results. Therefore, this meta-analysis was performed to assess the efficacy of triclosan-coated sutures for reducing risk of SSI in adults.

Methods

PubMed, EMBASE, Google Scholar, and ClinicalTrials.gov were searched to identify randomized clinical trials evaluating triclosan-coated sutures for preventing SSI on patients 18 y or older.

Results

Thirteen randomized clinical trials involving 5256 participants were included. Triclosan-coated sutures were associated with lower risk of SSI than uncoated sutures across all surgeries (risk ratio [RR] 0.76, 95% confidence interval [CI] 0.65–0.88, P < 0.001). Similar proportions of patients experienced wound dehiscence with either type of suture (RR 0.97, 95% CI 0.49–1.89, P = 0.92). Subgroup analysis showed lower risk of SSI with triclosan-coated sutures in abdominal surgeries (RR 0.70, 95% CI 0.50–0.99, P = 0.04) and group with prophylactic antibiotic (RR 0.79, 95% CI 0.63–0.99, P = 0.04). However, such risk reduction was not observed in cardiac surgeries, breast surgeries, or group without prophylactic antibiotic.

Conclusions

Triclosan-coated sutures can decrease the incidence of SSI in abdominal surgeries and might not interfere with wound healing process. Nevertheless, further studies are needed to examine whether triclosan-coated sutures are effective at preventing SSI in non-abdominal surgeries and to further study the interaction of antibiotic prophylaxis with triclosan-coated sutures.