Exogenous supplement of N-acetylneuraminic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice
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- 作者：Shoudong Guo ; SD-GUO@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Hua Tian ; Rongrong Dong ; Nana Yang ; Ying Zhang ; Shutong Yao ; Yongjun Li ; Yawei Zhou ; Yanhong Si ; Shucun Qin
- 关键词：Cardiovascular disease ; Sialic acid ; Anti-Oxidation ; Anti-inflammation ; Reverse cholesterol transport ; Quercetin
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：251
- 期：Complete
- 页码：183-191
- 全文大小：2411 K
文摘
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N-acetylneuraminic acid (NANA) decreased atherosclerotic plaque formation in apoE−/− mice.
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NANA dramatically reduced triglyceride via improving lipoprotein lipase activity.
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NANA notably lowered plasma total cholesterol by up-regulating reverse cholesterol transport.
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NANA notably decreased oxidative stress and inflammatory reaction.
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