The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice

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• 作者：Mei Liu ^{waitliumei@foxmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yu Zhang ^{chumenghen123@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hui Zhang ; ^{zhanghui@jiangnan.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{hardyzhang1990@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{happyzyjforever@126.com" class="auth_mail" title="E-mail the corresponding author} ; Bo Hu ^{615159020@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Li Wang ^{nmrwl@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author} ; Haifeng Qian ^{576589831@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Xiguang Qi ^{307957312@qq.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：β-d-glucan ; Diabetes ; Hepatogenic glycometabolism
• 刊名：International Journal of Biological Macromolecules
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：91
• 期：Complete
• 页码：1170-1176
• 全文大小：1520 K

文摘

This study was initiated to investigate the mechanism by which oat β-d-glucan (OBG) can control blood sugar levels and improve hepatogenic glycometabolism in streptozotocin-nicotinamide induced mice. After administration of different concentrations and molecular weights of β-d-glucan by oral gavage for 28 days, the body weight, fasting blood glucose, serum insulin, hepatic glycogen, glucose kinase and glucose-6-phosphatase activity of the diabetic mice were measured. In comparison with a negative control group (saline), β-d-glucan, especially medium or high doses of high-molecular-weight β-d-glucan, had a strong hypoglycaemic effect in streptozotocin-nicotinamide-induced mice. The mechanism of this effect may be associated with the high viscosity of the solution, an increase in insulin secretion, a decline in insulin resistance, and especially an improvement in hepatogenic glycometabolism. Moreover, β-d-glucan also markedly repaired and improved the integrity of pancreatic islet β-cell and tissue structures.