Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats
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- 作者：Aijie zhanga ; c ; zhangaijie1986@163.com" class="auth_mail" title="E-mail the corresponding author ; Yongming Jiaa ; yongmingjiahlj@126.com" class="auth_mail" title="E-mail the corresponding author ; Qinghan Xua ; xulianglinyao@126.com" class="auth_mail" title="E-mail the corresponding author ; Changyuan Wanga ; b ; wangcyuan@163.com" class="auth_mail" title="E-mail the corresponding author ; Qi Liua ; b ; llaqii@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author ; Qiang Menga ; b ; mengq531@yahoo.cn" class="auth_mail" title="E-mail the corresponding author ; Jinyong Penga ; b ; jinyongpeng2005@163.com" class="auth_mail" title="E-mail the corresponding author ; Huijun Suna ; b ; sunhuijun@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Pengyuan Suna ; spfar1004@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Xiaokui Huoa ; b ; huoxiaokui@163.com" class="auth_mail" title="E-mail the corresponding author ; Kexin Liua ; b ; kexinliu@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT ; alanine amiotransferase ; ANIT ; alpha-naphthylisothiocyanate ; AST ; aspartate transaminase ; BIL ; bilirubin ; Bsep ; bile salt export pump ; CMC-Na ; carboxymethylcellulose sodium ; E3S ; estrone-3-sulfate ; FXR ; Farnesoid X receptor ; IS ; hydrochlorothiazide ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; Mrp ; multidrug resistance-associated protein ; Ntcp ; Na+-taurocholate cotransporting polypeptide ; Oatp ; organic anion transporting polypeptide ; qRT-PCR ; Quantitive Real Time-polymerase cha
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：127-135
- 全文大小：1757 K
文摘
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Cholestasis was improved by dioscin via up-regulating the expression of Oatps, Mrp2 and Bsep.
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Dioscin regulated Mrp2 and Bsep via activating FXR.
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Dioscin may be a candidate drug for the prevention of intrahepatic cholestasis.
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