Chromium (VI) potentiates the DNA adducts (O6-methylguanine) formation of N-nitrosodimethylamine in rat: Implication on carcinogenic risk
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- 作者：Fujun Ma ; Zhaobin Zhang ; Jieqiong Jiang ; Jianying Hu ; hujy@urban.pku.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cr(VI) ; Nitrosamines ; DNA adduct ; CYP 2E1 enzyme activity ; GSH
- 刊名：Chemosphere
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：139
- 期：Complete
- 页码：256-259
- 全文大小：342 K
文摘
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Cr(VI) synergistically enhanced the O6-MeG formation of NDMA in rat hepatic tissues.
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Cr(VI) did not alter the CYP 2E1 enzyme activity.
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Cr(VI) exposure decreased the GSH content in rats.