TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel
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- 作者：Qiao-Chu Wang1 ; 8 ; Qiaoxia Zheng1 ; 8 ; Haiyan Tan2 ; 8 ; Bing Zhang3 ; 8 ; Xiaoling Li1 ; 8 ; Yuxiu Yang3 ; Jie Yu4 ; Yang Liu5 ; Hao Chai3 ; Xi Wang1 ; Zhongshuai Sun5 ; Jiu-Qiang Wang1 ; Shu Zhu1 ; Fengli Wang1 ; Maojun Yang4 ; Caixia Guo5 ; Heng Wang6 ; Qingyin Zheng7 ; Yang Li3 ; 9 ; Quan Chen1 ; 9 ; Aimin Zhou2 ; a.zhou@csuohio.edu" class="auth_mail" title="E-mail the corresponding author ; Tie-Shan Tang1 ; tangtsh@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：165
- 期：6
- 页码：1454-1466
- 全文大小：5598 K
文摘
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TMCO1 gene encodes an evolutionarily conserved ER transmembrane-spanning protein
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Loss of TMCO1 causes overloading of ER Ca2+ store and mishandling of Ca2+ signaling
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TMCO1 assembles into a Ca2+ selective channel in response to ER Ca2+ overloading
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Ca2+ channel function of TMCO1 is disrupted by CFT dysplasia spectrum mutations