The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells

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• 作者：Ying-ying Li^a ; ^b ; Zheng-ming Shi^c ; Xiao-tong Yu^a ; ^b ; Ping Feng^a ; Xue-Jiang Wang^a ; ^b ; ^{xjwang@ccmu.edu.cn}
• 关键词：Urotensin II ; Migration ; Invasion ; NADPH oxidase ; JNK ; Human hepatoma cells
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：106-114
• 全文大小：3768 K
• 卷排序：88

文摘

UII mediated migration and invasion and increased MMP9/2 expression in hepatoma cells. NADPH oxidase-derived ROS mediated migration and invasion and MMP9/2 upregulation by UII. JNK activation by ROS mediated the migration and invasion and upregulation of MMP9/2 in response to UII. UII induced actin polymerization and fascin expression through ROS by the JNK pathway.