MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B
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- 作者：Jing Hu1 ; Tao Sun1 ; Hui Wang1 ; Zhengxin Chen4 ; Shuai Wang5 ; Lifeng Yuan1 ; Tingyu Liu1 ; Hai-Ri Li6 ; Pingping Wang6 ; Yukuan Feng6 ; 7 ; Qinhong Wang1 ; Roger E. McLendon2 ; Allan H. Friedman2 ; Stephen T. Keir2 ; Darell D. Bigner2 ; Jeff Rathmell1 ; Xiang-dong Fu6 ; Qi-Jing Li3 ; Huibo Wang4 ; Xiao-Fan Wang1 ; xiao.fan.wang@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 January 2016
- 年：2016
- 卷：29
- 期：1
- 页码：49-60
- 全文大小：2579 K
文摘
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Hypoxia-induced miR-215 is required for GIC survival and GBM progression
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Biogenesis of miR-215 is enhanced post-transcriptionally by HIF-Drosha interaction
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MiR-215 suppresses KDM1B expression and modulates activities of multiple pathways
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MiR-215 level correlates with level of HIF1α, KDM1B, and GBM progression in patients