Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers

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• 作者：Chen Gao^a ; ¹ ; Zhini He^a ; ¹ ; Jie Li^a ; Xiao Li^a ; Qing Bai^a ; Zhengbao Zhang^a ; Xiao Zhang^b ; Shan Wang^a ; Xinhua Xiao^a ; Fangping Wang^a ; Yan Yan^c ; Daochuan Li^a ; Liping Chen^a ; Xiaowen Zeng^a ; Yongmei Xiao^a ; Guanghui Dong^a ; Yuxin Zheng^b ; Qing Wang^a ; ^{wangq27@mail.sysu.edu.cn} ; Wen Chen^a ; ^{chenwen@mail.sysu.edu.cn}
• 关键词：PAHs ; polycyclic aromatic hydrocarbons ; PBLCs ; peripheral blood lymphocytes ; 1-OHP ; 1-hydroxypyrene ; lncRNAs ; long non-coding RNAs ; HOTAIR ; HOX transcript antisense RNA ; MALAT1 ; metastasis-associated lung adenocarcinoma transcript 1 ; TUG1 ; taurine up-regulated 1 ; GAS5 ; growth arrest-specific 5 ; H2K27me3 ; histone 3 lysine 27 trimethylation
• 刊名：Toxicology Reports
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：160-166
• 全文大小：822 K
• 卷排序：3

文摘

HOTAIR and MALAT1 were upregulated in PBLCs of PAHs-exposed workers. HOTAIR and MALAT1 expression was positively associated with the degree of DNA damage induced by PAHs. H3K27me3 modification was positively correlated with the degree of genetic damage and the increase of HOTAIR expression.