A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development

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• 作者：Da-wei Wang^a ; ¹ ; Liwen Wu^b ; ¹ ; Yang Cao^a ; Lei Yang^a ; Wei Liu^a ; Xiao-qiang E^a ; Guangrong Ji^c ; Zheng-gang Bi^a ; ^{zhenggangbi08@126.com}
• 关键词：mTORC1 ; Serine/glycine ; Proliferation ; Antioxidant ; Osteosarcoma
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：107-114
• 全文大小：1454 K
• 卷排序：29

文摘

Inhibition of mTORC1 pathway may reduce serine and glycine contents in osteosarcoma cells. mTORC1/serine/glycine metabolic axis promotes osteosarcoma proliferation and antioxidant ability to environmental stress. Our findings showed a novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma cells. The present findings will help to provide new opportunities for drug development in osteosarcoma clinical therapy.