Kaempferol slows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammation response in BMSCs

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• 作者：Jun Zhu ; Haoyu Tang ; Zhenhua Zhang ; Yong Zhang ; Chengfeng Qiu ; Ling Zhang ; Pinge Huang ; Feng Li ; ^{orthop_lifeng@163.com}
• 关键词：IVD ; intervertebral disc ; BMSCs ; mesenchymal stem cells ; LPS ; lipopolysaccharide ; PCNA ; proliferation cell nuclear antigen ; MMP ; matrix metalloprotease ; CPT-1 ; carnitine palmitoyl transferase-1 ; PPAR-γ ; peroxisome proliferators-activated receptor-γ ; IL ; interleukin ; NF-κB ; nuclear transcription factor-κB ; ADAMTS ; a disintegrin and metalloproteinase with thrombospondin motifs ; ACC ; acetyl coenzyme A carboxylase ; SREBP-1c ; sterol regulatory element binding proteins-1c ; FAS ; fatty acid synthetase
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：236-242
• 全文大小：1374 K
• 卷排序：43

文摘

Kaempferol enhances the viability of BMSCs. Kaempferol inhibits LPS-induced matrix degradation. Kaempferol decreases LPS-induced lipid accumulation in BMSCs. Kaempferol inhibits LPS-induced activation of the NF-κB in BMSCs.