Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement
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- 作者：Tingting Wang ; M.D.a ; b ; 1 ; Lei Zhang ; M.D. ; Ph.D.c ; 1 ; Jianqiang Hu ; M.D.a ; b ; 1 ; Yu Duan ; M.D.a ; 1 ; Mingming Zhang ; M.D.a ; b ; Jie Lin ; M.D.a ; b ; Wanrong Man ; M.D.a ; b ; Xietian Pan ; M.D.a ; b ; Zhenhua Jiang ; M.D.a ; Guoyong Zhang ; M.D.a ; Beilei Gao ; M.D.a ; Haichang Wang ; M.D. ; Ph.D.a ; b ; wanghc@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Dongdong Sun ; M.D. ; Ph.D.a ; b ; wintersun3@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Autophagy ; Mammalian Ste20-like kinase 1 ; Mst1 ; Macrophages
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：98
- 期：Complete
- 页码：108-116
- 全文大小：1815 K
文摘
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Mst1 is proposed as a new target for treating atherosclerosis.
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The mechanism relies on stabilization of vulnerable plaque.
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Macrophage autophagy and apoptosis should be modulated to inhibit atherosclerosis.