One-pot stereoselective synthesis of chiral 1, 3-oxathiolane by Trichosporon laibachii lipase: Optimization by response surface methodology integrated a desirability function approach
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- 作者：Yuanyuan Zhang ; Xin Gao ; Caiyun Wang ; Zhenkun Zheng ; Lulu Wang ; Junhong Liu ; liujh@qust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：1 ; 3-Oxathiolane ; Lipase ; Response surface methodology ; Desirability function ; Stereoselective synthesis
- 刊名：Journal of Molecular Catalysis B: Enzymatic
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：27-34
- 全文大小：2010 K
文摘
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A one-pot process for chiral 1,3-oxathiolane catalyzed by lipase is proposed.
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Response surface methodology integrated a desirability function approach are used.
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A good correlation between the predicted and actual responses is obtained.