Downregulation of HDAC9 inhibits cell proliferation and tumor formation by inducing cell cycle arrest in retinoblastoma
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- 作者：Yiting Zhanga ; Dan Wua ; Fengjie Xiaa ; Hongyu Xiana ; Xinyue Zhua ; Hongjuan Cuib ; hcui@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; hongjuan.cui@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhenping Huanga ; huangzhenping19633@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HDAC9 ; Retinoblastoma ; Cell proliferation ; Cell cycle ; Tumor formation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：600-606
- 全文大小：1458 K
文摘
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High expression of HDAC9 correlates with poor patient prognosis.
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Downregulation of HDAC9 inhibits cell proliferation in retinoblastoma cells.
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Downregulation of HDAC9 induces cell cycle arrest at G1 phase in retinoblastoma cells.
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Downregulation of HDAC9 suppresses tumor growth in nude mice.