The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity

详细信息    查看全文

• 作者：Li Yin^a ; Yanlin Dai^a ; ^b ; Zhihong Cui^a ; Xiao Jiang^a ; Wenbin Liu^a ; Fei Han^a ; Ao Lin^a ; Jia Cao^a ; Jinyi Liu^a ; ^{jinyiliutmmu@163.com}
• 关键词：AIF ; apoptosis-inducing factor ; ATF6 ; activating transcription factor 6 ; BPA ; bisphenol A ; CHOP ; CCAAT/enhancer-binding protein-homologous protein ; Cyt-c ; cytochrome complex ; EdU ; 5-ethynyl-2&prime ; -deoxyuridine ; EIF2α ; eukaryotic initiation factor 2 α ; ER ; endoplasmic reticulum ; GRP78 ; glucose-regulated protein 78 ; IRE-1 ; inositol-requiring enzyme 1 ; PERK ; protein kinase RNA-like endoplasmic reticulum kinase ; ROS ; reactive oxygen species ; siRNA ; small interfering RNA ; UPR ; unfolded protein resp
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：98-108
• 全文大小：2720 K
• 卷排序：314

文摘

BPA exposure caused the damage of the endoplasmic reticulum. BPA exposure activated ER stress related proteins in male reproductive system. ROS regulated PERK/EIF2α/chop pathway played a vital role in BPA-induced toxicity.