- 作者：Wenbin Guo ; Changqing Xiao ; Guiying Liu ; Sarah C. Wooderson ; Zhikun Zhang ; Jian Zhang ; Liuyu Yu ; Jianrong Liu
- 关键词：fMRI ; functional magnetic resonance imaging ; FC ; functional connectivity ; BOLD ; blood oxygen level-dependent ; ACC ; anterior cingulate cortex ; DMN ; default mode network ; R-fMRI ; resting-state fMRI ; VMHC ; voxel-mirrored homotopic connectivity ; SCID ; Structured Clinical Interview of the DSM-IV ; DUP ; duration of untreated psychosis ; PANSS ; Positive and Negative Symptom Scale ; TR/TE ; repetition time/echo time ; FOV ; field of view ; ROI ; region of interest ; GRF ; Gaussian Random Field ; FD ; framewise disp
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：3 January, 2014
- 年：2014
- 卷：48
- 期：Complete
- 页码：14-19
- 全文大小：695 K
Background
Dysconnectivity hypothesis posits that schizophrenia relates to abnormalities in neuronal connectivity. However, little is known about the alterations of the interhemispheric resting-state functional connectivity (FC) in patients with paranoid schizophrenia. In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to investigate the interhemispheric FC of the whole brain in patients with paranoid schizophrenia at rest.Methods
Forty-nine first-episode, drug-naive patients with paranoid schizophrenia and 50 age-, gender-, and education-matched healthy subjects underwent a resting-state functional magnetic resonance imaging (fMRI) scans. An automated VMHC approach was used to analyze the data.
Results
Patients exhibited lower VMHC than healthy subjects in the precuneus (PCu), the precentral gyrus, the superior temporal gyrus (STG), the middle occipital gyrus (MOG), and the fusiform gyrus/cerebellum lobule VI. No region showed greater VMHC in the patient group than in the control group. Significantly negative correlation was observed between VMHC in the precentral gyrus and the PANSS positive/total scores, and between VMHC in the STG and the PANSS positive/negative/total scores.
Conclusions
Our results suggest that interhemispheric resting-state FC of VMHC is reduced in paranoid schizophrenia with clinical implications for psychiatric symptomatology thus further contribute to the dysconnectivity hypothesis of schizophrenia.