GYF-17, a chloride substituted 2-(2-phenethyl)-chromone, suppresses LPS-induced inflammatory mediator production in RAW264.7 cells by inhibiting STAT1/3 and ERK1/2 signaling pathways
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- 作者：Zhixiang Zhu ; Yufan Gu ; Yunfang Zhao ; Yuelin Song ; Jun Li ; drlj666@163.com" class="auth_mail" title="E-mail the corresponding author ; Pengfei Tu ; pengfeitu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：GYF-17 ; 2-(2-phenethyl)-chromone ; RAW264.7 cells ; Inflammation ; STAT1/3 ; ERK1/2
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：185-192
- 全文大小：1554 K
文摘
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GYF-17 inhibited NO production and expression of iNOS;
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GYF-17 inhibited expression and secretion of TNF-α, IL-6 and IL-1β;
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GYF-17 inhibited PGE2 production and expression of COX2;
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GYF-17 inhibited activation of STAT1/3 and ERK1/2 signaling pathways;