Adipose Snail1 Regulates Lipolysis and Lipid Partitioning by Suppressing Adipose Triacylglycerol Lipase Expression
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- 作者：Chengxin Sun1 ; 2 ; 5 ; Lin Jiang2 ; 5 ; Yan Liu2 ; Hong Shen2 ; Stephen J. Weiss3 ; 4 ; Yifa Zhou1 ; zhouyf383@nenu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liangyou Rui2 ; 4 ; 6 ; ruily@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：obesity ; insulin resistance ; type 2 diabetes ; liver steatosis ; NAFLD ; lipolysis ; adipocytes ; hepatocytes ; Snail1 ; ATGL
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：17
- 期：8
- 页码：2015-2027
- 全文大小：4368 K
文摘
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Insulin increases Snail1 levels in white adipocytes
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Snail1 represses ATGL expression and suppresses lipolysis
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Adipocyte-specific deletion of Snail1 decreases adipocyte size and adiposity
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Adipocyte-specific deletion of Snail1 promotes liver steatosis in mice
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