Diversity-oriented one-pot multicomponent synthesis of spirooxindole derivatives and their biological evaluation for anticancer activities

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• 作者：Jun Yang^a ; ¹ ; Xiong-Wei Liu^a ; ¹ ; Dan-Dan Wang^a ; Min-Yi Tian^a ; Shuo-Nan Han^a ; Ting-Ting Feng^a ; Xiong-Li Liu^a ; ^{xlliu1@gzu.edu.cn} ; Ren-Qiang Mei^b ; Ying Zhou^a ; ^{yingzhou71@yeah.net}
• 关键词：Five-membered carbocyclic spirooxindoles ; One-pot multicomponent synthesis ; Knoevenagel condensation/Michael/cyclization ; Aminomethylation ; Antitumor activity
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：29 December 2016
• 年：2016
• 卷：72
• 期：52
• 页码：8523-8536
• 全文大小：2552 K
• 卷排序：72

文摘

A methodology for synthesis of spirooxindole derivatives was developed. Products were obtained smoothly with high efficiency. Promising activities against three human cancer cell lines have been demonstrated.