Toxicology of 3-epi-deoxynivalenol, a deoxynivalenol-transformation product by Devosia mutans 17-2-E-8

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Toxicology of 3-epi-deoxynivalenol, a deoxynivalenol-transformation product by Devosia mutans 17-2-E-8

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作者：Jian Wei He^a ; ^b ; Genevieve S. Bondy^c ; ^{genevieve.bondy@hc-sc.gc.ca" class="auth_mail" title="E-mail the corresponding author} ; Ting Zhou^a ; ^{Ting.Zhou@agr.gc.ca" class="auth_mail" title="E-mail the corresponding author} ; Don Caldwell^c ; Greg J. Boland^b ; Peter M. Scott^c
关键词：Deoxynivalenol ; Vomitoxin ; DON ; 3-epi-DON ; Cytotoxicity ; BrdU bioassay ; 3T3 fibroblasts cell line ; MTT bioassay ; Caco-2 cell line ; B6C3F1 mouse
刊名：Food and Chemical Toxicology
出版年：2015
出版时间：October 2015
年：2015
卷：84
期：Complete
页码：250-259
全文大小：1524 K

文摘

bel">•: The ICb>50b> value of 3-epi-DON was 357 times higher than DON in a MTT bioassay.
bel">•: The ICb>50b> value of 3-epi-DON was 1181 times higher than that of DON in a BrdU assay.
bel">•: 3-epi-DON was at least 50 times less toxic than DON in B6C3Fb>1b> mice.

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