MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN
详细信息 查看全文
- 作者：Ting-Song Yang1 ; surgeonyts@163.com" class="auth_mail ; Xiao-Hu Yang1 ; shuaitiger@163.com" class="auth_mail ; Xi Chen1 ; beautycici@163.com" class="auth_mail ; Xu-Dong Wang wxd19831208@163.com" class="auth_mail ; Jie Hua surgeonhuajie@hotmail.com" class="auth_mail ; Dong-Lei Zhou surgeonytszdl@hotmail.com" class="auth_mail ; Bo Zhou surgeonzhoubo@163.com" class="auth_mail ; Zhen-Shun Song ; songzhenshun@hotmail.com" class="auth_mail
- 关键词：CAFs ; cancer associated fibroblasts ; NFs ; normal fibroblasts ; miRNA ; microRNA ; PTEN ; protein tyrosine phosphatase and tensin homologue ; 伪-SMA ; 伪-smooth muscle actin ; FSP1 ; fibroblast specific protein 1 ; FAP ; fibroblast activation protein ; TGF-尾 ; transforming growth factor-尾 ; HGF ; hepatocyte growth factor ; PDGF ; platelet-derived growth factor ; FGF-7 ; fibroblast growth factor-7 ; SDF-1 ; stromal cell-derived factor-1
- 刊名：FEBS Letters
- 出版年：13 June 2014
- 年：2014
- 卷：588
- 期：13
- 页码：2162-2169
- 全文大小：1829 K
文摘
- •
MiR-106b is up-regulated in CAFs compared to NFs in gastric cancer.
- •
Down-regulation of miR-106b in CAFs inhibits cancer cell motility by targeting PTEN.
- •
MiR-106b might be a potential therapeutic target for gastric cancer.