In vivo fate of lipid-based nanoparticles

详细信息    查看全文

• 作者：Jianping Qi¹ ; ⁴ ; Jie Zhuang² ; ⁴ ; Yi Lu¹ ; Xiaochun Dong¹ ; Weili Zhao¹ ; ³ ; Wei Wu¹ ; ^{wuwei@shmu.edu.cn}
• 刊名：Drug Discovery Today
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：166-172
• 全文大小：1790 K
• 卷排序：22

文摘

LBNs are readily degradable through lipolysis by lipases. LBNs that survive lipolysis can be translocated to various organs and tissues. Lipid composition, particle size, surface decorations and protein corona are the main factors influencing in vivo fate of LBNs. Lipolysis of LBNs in vivo can be visualized by labeling with environment-responsive fluorescent probes.