Novel benzimidazole derivatives as selective CB2 agonists
详细信息 查看全文
- 作者：Daniel Pagé ; Elise Balaux ; Luc Boisvert ; Ziping Liu ; Claire Milburn ; Maxime Tremblay ; Zhongyong Wei ; Simon Woo ; Xuehong Luo ; Yun-Xing Cheng ; Hua Yang ; Sanjay Srivastava ; Fei Zhou ; William Brown
- 关键词：Cannabinoids ; Benzimidazoles ; CB2 receptor ; Agonists
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：1 July 2008
- 年：2008
- 卷：18
- 期：13
- 页码：3695-3700
- 全文大小：200 K
文摘
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.