PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2

详细信息    查看全文

• 作者：Soumyananda Chakraborti^a ; ¹ ; ² ; Samik Chakraborty^b ; ¹ ; ³ ; Shilpi Saha^b ; Argha Manna^b ; Shruti Banerjee^b ; Arghya Adhikary^b ; ⁴ ; Shamila Sarwar^a ; Tapas K. Hazra^c ; Tanya Das^b ; ^{tanya@jcbose.ac.in} ; Pinak Chakrabarti^a ; ^{pinak@jcbose.ac.in}
• 关键词：Apoptosis ; Breast cancer ; NEIL2 ; p53 ; PEG-ZnO nanoparticles ; ROS ; Sp1
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：35-47
• 全文大小：1845 K
• 卷排序：103

文摘

PEG-coated ZnO nanoparticles (PEG-ZnO NPs) have greater stability than ZnO NPs. PEG-ZnO NPs have significant anti-tumor activity against human breast cancer cells. DNA repair or apoptosis occurs depending on ROS level in a time-dependent manner. There is ROS-NEIL2 cross-talk in deciding cell fate during PEG-ZnO NP treatment.