Layered nanohydroxyapatite as a novel nanocarrier for controlled delivery of 5-fluorouracil
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- 作者：Honglin Luoa ; b ; Dehui Jia ; Chunzhi Lia ; Yong Zhuc ; Guangyao Xionga ; b ; xiongguangyao@163.com" class="auth_mail" title="E-mail the corresponding author ; Yizao Wana ; b ; yzwantju@126.com" class="auth_mail" title="E-mail the corresponding author ; yzwan@tju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Layered hydroxyapatite ; 5-Fluorouracil ; Intercalation ; Controlled release
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：513
- 期：1-2
- 页码：17-25
- 全文大小：2611 K
文摘
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A novel drug carrier based on layered nanohydroxyapatite (L-nHAp) was synthesized.
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The intercalation of 5-fluorouracil (5FU) into the gallery of L-nHAp is evidenced.
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The loading amount of 5FU in L-nHAp is as high as 130.1 mg/g.
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The release of 5FU from L-nHAp/5FU was more controllable than rodlike HAp counterpart.