A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors

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• 作者：Alexandre Iannello^a ; Suzanne Samarani^a ; Ossama Allam^a ; Mohammad-Ali Jenabian^b ; Vikram Mehraj^c ; Devendra Amre^d ; Jean-Pierre Routy^c ; Cé ; cile Tremblay^e ; Ali Ahmad^a ; ^{ali.ahmad@recherche-ste-justine.qc.ca}
• 关键词：AIDS ; IL-18 ; IL-18BP ; HIV-1 ; Long-Term Non-Progressors
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：96-99
• 全文大小：376 K
• 卷排序：90

文摘

IL-18BP, an antagonist of IL-18, production decreases in HIV infected individuals. No increase in production of IFN-γ in HIV infection may underlie this decrease. Its production is maintained at normal physiological levels in LTNP. The antagonist levels correlate negatively with viral loads. The levels tend to correlate positively with CD4+ T cell counts.