Browning and thermogenic programing of adipose tissue

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• 作者：Florian W. Kiefer ; MD ; PhD ^{florian.kiefer@meduniwien.ac.at" class="auth_mail" title="E-mail the corresponding author} (Assistant Professor in Medicine)
• 关键词：beige and brown adipocytes ; thermogenesis ; energy expenditure
• 刊名：Best Practice Research Clinical Endocrinology Metabolism
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：4
• 页码：479-485
• 全文大小：544 K

文摘

The view of adipose tissue as solely a fat storing organ has changed significantly over the past two decades with the discoveries of numerous adipocyte-secreted factors, so called adipokines, and their endocrine functions throughout the body. The newest chapter added to this story is the finding that adipose tissue is also a thermogenic organ contributing to energy expenditure through actions of specialized, heat-producing brown or beige adipocytes. In contrast to bone fide brown adipocytes, beige cells develop within white fat depots in response to various stimuli such as prolonged cold exposure, underscoring the great thermogenic plasticity of adipose tissue. The energy dissipating properties of beige and/or brown adipocytes hold great promise as a novel therapeutic concept against obesity and related complications. Hence, identifying the specific thermogenic adipocyte populations in humans and their pathways of activation are key milestones of current metabolism research. Here we will discuss the recent advances in the understanding of the molecular and physiological mechanisms of adipose tissue browning.