Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis

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• 作者：Grant A. Challen¹ ; ^{grantchallen@wustl.edu}
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：7-8
• 全文大小：175 K
• 卷排序：20

文摘

Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.