Morphine-induced antinociception and reward in “humanized” mice expressing the mu opioid receptor A118G polymorphism
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- 作者：Angela N. Henderson-Redmonda ; Matthew B. Yuilla ; b ; c ; Tammy E. Lowea ; d ; Aaron M. Klinea ; Michael L. Zeea ; José ; e Guindone ; josee.guindon@ttuhsc.edu" class="auth_mail" title="E-mail the corresponding author ; Daniel J. Morgana ; b ; c ; dmorgan1@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; AUC ; area under the curve ; BT ; body temperature ; CPP ; conditioned place preference ; DAMGO ; [D-Ala2 ; N-MePhe4 ; and Gly-ol]-enkephalin ; ICSS ; intra-cranial self-stimulation ; IP ; intraperitoneal ; MPE ; maximal possible effect ; MOR ; mu-opioid receptor ; PCA ; patient-controlledanalgesia ; SII ; secondary somatosensory ; SNP ; single nucleotide polymorphism ; SC ; subcutaneous
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：5-12
- 全文大小：1575 K
文摘
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Expression of the A118G polymorphism in mice does not disrupt morphine reward.
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The A118G polymorphism reduces morphine-induced antinociception.
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The A118G polymorphism does not affect morphine tolerance.
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The A118G polymorphism does not change the basal response to inflammatory pain.
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