Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway

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• 作者：Nazish Abdullah¹ ; Muheeb Beg¹ ; David Soares¹ ; Jeremy S. Dittman¹ ; Timothy E. McGraw¹ ; ² ; ³ ; ^{temcgraw@med.cornell.edu}
• 关键词：GIP ; GIP receptor ; GPCR ; GPCR trafficking ; incretin ; beta arrestin ; GRK ; GIPR downregulation
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：2966-2978
• 全文大小：2910 K
• 卷排序：17

文摘

GIP causes GIPR downregulation by phosphorylation-mediated β-arrestin2 recruitment β-arrestin2 mediates GIPR sorting from endosomes to TGN upon GIP stimulation GIPR targeting from endosomes to slow recycling TGN causes downregulation A coding variant (Gln354) is targeted to TGN in the absence of phosphorylation