Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice

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• 作者：M. Carmen Blanco-Gand&iacute ; a^a ; L&iacute ; dia Cantacorps^b ; Auxiliadora Aracil-Ferná ; ndez^c ; Sandra Montagud-Romero^a ; Mar&iacute ; a A. Aguilar^a ; Jorge Manzanares^c ; Olga Valverde^b ; José ; Miñ ; arro^a ; Marta Rodr&iacute ; guez-Arias^a ; ^{marta.rodriguez@uv.es}
• 关键词：Binge eating ; Fat ; Cocaine ; Conditioned place preference ; Self-administration ; Gene expression
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：31-44
• 全文大小：822 K
• 卷排序：113

文摘

High-fat binging increases sensitivity to cocaine in the conditioned place preference. High-fat binging enhances acquisition and reinstatement of cocaine self-administration. High-fat binging reduces MOr and CB1r gene expression in the Nucleus Accumbens. High-fat binging increases ghrelin receptor expression in the ventral tegmental area. Fat withdrawal prolongs extinction and facilitates reinstatement of the preference.