Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1)

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• 作者：Sven Marcel Schmitt¹ ; Katja Stefan¹ ; Michael Wiese ; ^{mwiese@uni-bonn.de}
• 关键词：ABC ; ATP-binding cassette ; ABCB1 ; synonymous for P-gp ; ABCC1 ; synonymous for MRP1 ; ABCG2 ; synonymous for BCRP ; APT ; attached proton test ; ATP ; adenosine 5&prime ; -triphosphate ; BCECF ; 2&prime ; .7&prime ; -bis(2-carboxyethyl)-5-(and-6)-carboxyfluorescein ; BCPCF ; 3-carboxy-propyl-5-(and-6-)-carboxyfluorescein ; BCRP ; Breast Cancer Resistance Protein ; calcein AM ; calcein acetoxymethyl ester ; δ ; chemical shift in ppm ; DAD ; diode array detector ; DEPT ; distortion less enhancement by polarization transfer
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：69-79
• 全文大小：1267 K
• 卷排序：1859

文摘

New classes of selective MRP1 activators Compounds acting as non-essential activators Discovery of a triple inhibitor of MRP1, P-gp, BCRP