- 作者：Chun-mu Miao ; Xiao-wei Jiang ; Kun He ; Pei-zhi Li ; Zuo-jin Liu ; Ding Cao ; Zhi-bing Ou ; Jian-ping Gong ; Chang-an Liu ; liuchangan120@163.com" class="auth_mail" title="E-mail the corresponding author ; Yao Cheng ; 124139153@QQ.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kupffer cells ; BMSCs ; NLRP3 ; PGE2 ; Acute liver injury
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：179
- 期：Complete
- 页码：102-113
- 全文大小：4908 K
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The expressions of NLRP3, ASC and caspase-1 in KCs of mice liver and in co-culture system and the pro-inflammatory cytokines in the supernatant were reduced significantly in the BMSC-treated group compared to the LPS group.
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PGE2 over-expression strengthened the anti-inflammatory ability of BMSCs, but silencing PGE2 reversed this anti-inflammatory effect.
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The IL-10 levels in the serum of mice and supernatant of co-culture system were up-regulated by the BMSC treatment. While, ERK1 inhibitor reduced IL-10 production in KCs and blocked the inhibitory effect of PGE2 on the activation of the NLRP3 inflammasome.
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Our data reveal a novel mechanism of BMSC-mediated suppression of the activation of KCs through secretion of PGE2 by BMSCs, which promotes KCs to secrete IL-10, leading to the inhibition of the NLRP3 inflammasome in KCs.