Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway
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- 作者：Dae-Hwan Nama ; Jung-Hwa Hana ; Suji Kima ; YoungHyun Shinb ; Jae Hyang Limc ; Hyoung Chul Choia ; Chang-Hoon Wooa ; changhoon_woo@yu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Methylglyoxal ; CHOP ; ER stress ; APC ; AMPK ; Cardiomyocyte
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：622-628
- 全文大小：1664 K
文摘
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APC inhibits MGO-induced myocyte apoptosis via inhibition of ER stress.
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APC prevents MGO-induced ROS generation and Ca2+ mobilization in cardiomyocytes.
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APC prevents MGO-induced ER stress and apoptosis through AMPK signaling.