Deubiquitination and Stabilization of PD-L1 by CSN5

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• 作者：Seung-Oe Lim¹ ; ⁹ ; Chia-Wei Li¹ ; ⁹ ; Weiya Xia¹ ; Jong-Ho Cha¹ ; ⁵ ; Li-Chuan Chan¹ ; ⁴ ; Yun Wu² ; Shih-Shin Chang¹ ; ⁴ ; Wan-Chi Lin¹ ; Jung-Mao Hsu¹ ; Yi-Hsin Hsu¹ ; Taewan Kim¹ ; Wei-Chao Chang⁶ ; Jennifer L. Hsu¹ ; ⁶ ; Hirohito Yamaguchi¹ ; Qingqing Ding¹ ; Yan Wang¹ ; Yi Yang¹ ; Chung-Hsuan Chen⁸ ; Aysegul A. Sahin² ; Dihua Yu¹ ; ⁴ ; Gabriel N. Hortobagyi³ ; Mien-Chie Hung¹ ; ⁴ ; ⁶ ; ⁷ ; ¹⁰ ; ^{mhung@mdanderson.org}
• 关键词：deubiquitination ; curcumin ; anti-CTLA4 ; TNF-α ; CSN5 ; PD-L1
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：12 December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：925-939
• 全文大小：6167 K
• 卷排序：30

文摘

TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy