Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis

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• 作者：Eunhee Han^a ; ¹ ; Sung Jin Jo^a ; ¹ ; Hyeyoung Lee^a ; Ae-Ran Choi^a ; Jihyang Lim^a ; Eun-Sun Jung^b ; Eun-Jee Oh^a ; ^{ejoh@catholic.ac.kr}
• 关键词：Anti-mitochondrial autoantibodies ; Primary biliary cirrhosis ; Anti-mitochondrial antibody M2 subtype ; Combined test ; Diagnosis
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：464
• 期：Complete
• 页码：113-117
• 全文大小：283 K
• 卷排序：464

文摘

IIF with cut-off value of 1:80 has high specificity for AMA detection. Assays using recombinant E3 antigens had high sensitivity for PBC diagnosis. IIF with high titer cut-off and additional M2 specific tests in IIF-negative sera should be used for PBC diagnosis.