Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics

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• 作者：José ; Alexandre Ferreira^a ; ^b ; ^c ; ^d ; ^{jose.a.ferreira@ipoporto.min-saude.pt} ; Ana Magalhã ; es^b ; ^c ; Joana Gomes^b ; ^c ; Andreia Peixoto^a ; Cristiana Gaiteiro^a ; Elisabete Fernandes^a ; Lú ; cio Lara Santos^a ; ^e ; ^f ; Celso A. Reis^b ; ^c ; ^d ; ^g
• 关键词：Protein glycosylation ; Gastric cancer ; Colorectal cancer ; Targeted therapeutics ; Glycoprotomics ; Cancer glycans
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：387
• 期：Complete
• 页码：32-45
• 全文大小：3315 K
• 卷排序：387

文摘

Alterations in glycosylation are hallmarks of malignant transformation in the gastric and colorectal tract. Altered protein glycosylation favors malignant phenotypes and contributes to poor outcome. Advances in glycomics, glycoproteomics and glycoengineering have broadened our understanding of the human glycoproteome. A comprehensive glycomic and glycoproteomic characterization of human tumors will allow true precision medicine setting. Cancer-associated glycans hold tremendous potential for non-invasive cancer detection and targeted therapeutics.