Hyaluronan polymeric micelles for topical drug delivery
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- 作者：Daniela &Scaron ; mejkalová ; a ; Tomá ; &scaron ; Muthný ; a ; Kristina Ne&scaron ; porová ; a ; b ; kristina.nesporova@contipro.com" class="auth_mail" title="E-mail the corresponding author ; Martina Hermannová ; a ; Eva Achbergerová ; a ; c ; Gloria Huerta-Angelesa ; Marek Svobodaa ; d ; Martin Čepaa ; Veronika Machalová ; a ; Dominika Luptá ; ková ; e ; f ; Vladimí ; r Velebný ; a
- 关键词：Skin penetration ; Polymeric micelle ; Hyaluronan
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：86-96
- 全文大小：2656 K
文摘
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Hyaluronan polymeric micelles act as skin penetration enhancer.
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Transcellular penetration pathway is dominant.
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Both the loaded drug and hyaluronan reach epidermis and dermis.
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The hyaluronan carrier is disrupted in the stratum corneum.
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The loaded micelles are stable in cream formulations.