Neuropsychological dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease
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- 作者：Crews ; W. David ; Jefferson ; Angela L. ; Bolduc ; Tara ; Elliott ; Jennifer B. ; Ferro ; Nikola M. ; et. al.
- 关键词：Neuropsychological dysfunction ; Chronic obstructive pulmonary disease ; Lung transplantation
- 刊名：Archives of Clinical Neuropsychology
- 出版年：2001
- 出版时间：October, 2001
- 年：2001
- 卷：16
- 期：7
- 页码：643-652
- 全文大小：126 K
文摘
Few studies have examined the neuropsychological sequelae associated with end-stage pulmonary disease. Neuropsychological data are presented for 47 patients with end-stage chronic obstructive pulmonary disease (COPD) who were being evaluated as potential candidates for lung transplantation. Although patients exhibited a diversity of neurocognitive deficits, their highest frequencies of impairment were found on the Selective Reminding Test (SRT). Specifically, over 50 % of the patients completing the SRT exhibited impaired immediate free recall and consistent long-term retrieval deficits, while more than 44 % of these individuals displayed deficient long-term retrieval. Deficient SRT long-term storage strategies, cued recall, and delayed recall were exhibited by between 26 % and 35 % of these patients, while more than 32 % of this sample displayed elevated numbers of intrusion errors. Over 31 % of the patients completing the Wisconsin Card Sorting Test (WCST) failed to achieve the expected number of categories on this measure, while more than 23 % of these individuals demonstrated elevated numbers of perseverative errors and total errors. Clinically notable frequencies of impairment (greater than 20 % of the sample) were also found on the Trail Making Test (TMT): Part B and the Wechsler Memory Scale-R (WMS-R) Visual Reproduction II subtest. Minnesota Multiphasic Personality Inventory-2 (MMPI-2) personality assessments indicated that patients were experiencing a diversity of somatic complaints and that they may have been functioning at a reduced level of efficiency. These findings are discussed in light of patients' end-stage COPD and factors possibly contributing to their neuropsychological test performances. Implications for clinical practice and future research are also included.