Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

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• 作者：Ana Cordeiro Gomes¹ ; ² ; ¹¹ ; Takahiro Hara³ ; ¹¹ ; ^{thara@virus.kyoto-u.ac.jp} ; Vivian Y. Lim¹ ; ¹¹ ; Dietmar Herndler-Brandstetter¹ ; Erin Nevius¹ ; Tatsuki Sugiyama⁴ ; ⁵ ; Shizue Tani-ichi³ ; Susan Schlenner⁶ ; ⁷ ; Ellen Richie⁹ ; Hans-Reimer Rodewald⁸ ; Richard A. Flavell¹ ; ¹⁰ ; Takashi Nagasawa⁴ ; ⁵ ; Koichi Ikuta³ ; Joã ; o Pedro Pereira¹ ; ¹² ; ^{joao.pereira@yale.edu}
• 刊名：Immunity
• 出版年：2016
• 出版时间：20 December 2016
• 年：2016
• 卷：45
• 期：6
• 页码：1219-1231
• 全文大小：8392 K
• 卷排序：45

文摘

Hematopoietic multipotent progenitors require CXCR4 for multilineage differentiation IL-7 acts as a short-range signal for common lymphoid progenitor differentiation IL-7+ cells are CXCL12-abundant reticular mesenchymal progenitor cells CXCL12 and SCF expressed by IL-7+ cells control the number of HSCs and MPPs in BM