2,2鈥?Bipyridine derivatives containing aza-crown ether: Structure, two-photon absorption and bioimaging
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- 作者：Dongling Xu ; Zhipeng Yu ; Mingdi Yang ; Zheng Zheng ; Li Zhu ; Xiuzhen Zhang ; Lina Ye ; Jieying Wu ; Yupeng Tian ; Hongping Zhou
- 关键词：Aza-crown ether ; Dipyridine ; SPEF ; 未 ; MTT ; TPFM
- 刊名：Dyes and Pigments
- 出版年：January, 2014
- 年：2014
- 卷：100
- 期：Complete
- 页码：142-149
- 全文大小：2131 K
文摘
Two novel 6-phenyl-2,2鈥?bipyridine derivatives based on aza-crown ether groups were synthesized and characterized, one of which was characterized by single crystal X-ray diffraction determination. Their linear photophysical properties were systematically investigated in various solvents. The nonlinear photophysical properties were investigated by two-photon induced fluorescence method. Both dyes exhibited large two-photon absorption cross-section (未2PA). The cytotoxicity of the dyes was evaluated in HepG2 cell line to assess the potential application for biomedical imaging. Two-photon fluorescence microscopy (TPFM) imaging of two dyes in HepG2 cell line was demonstrated, which indicated that introduction of the hydrophilic aza-crown ether facilitates biological compatibility of dyes.