Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

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• 作者：Lin Kooi Ong^a ; ^b ; ^c ; Zidan Zhao^a ; ^b ; Murielle Kluge^a ; ^b ; Clifford TeBay^a ; Katarzyna Zalewska^a ; ^b ; Phillip W. Dickson^b ; ^d ; Sarah J. Johnson^e ; Michael Nilsson^a ; ^b ; ^c ; Frederick R. Walker^a ; ^b ; ^c ; ^{rohan.walker@newcastle.edu.au}
• 关键词：α-Synuclein ; Astrocytes ; Chronic stress ; Microglia ; Neurodegeneration ; Oxidative stress ; Substantia nigra
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：117-125
• 全文大小：2775 K
• 卷排序：60

文摘

Chronic stress triggers loss of dopaminergic neurons within the substantia nigra. Increased level of oxidative stress. Suppressed glia neuroprotective functions. Enhanced the aggregation of α-synuclein.