Probing the interaction between 7-O-β-d-glucopyranosyl-6-(3-methylbut-2-enyl)-5,4′-dihydroxyflavonol with bovine serum albumin (BSA)

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• 作者：Otá ; vio Augusto Chaves^a ; Dari Cesarin-Sobrinho^a ; Carlos Mauricio R. Sant&rsquo ; Anna^a ; Mario Geraldo de Carvalho^a ; Luciano Ramos Suzart^a ; Francisco Eduardo Aragã ; o Catunda-Junior^a ; Jos&eacute ; Carlos Netto-Ferreira^a ; ^b ; Aur&eacute ; lio B.B. Ferreira^a ; ^{aureliobf@uol.com.br}
• 关键词：Bovine serum albumin ; Ouratea hexasperma ; Flavonoid ; Fluorescence quenching ; Circular dichroism spectroscopy ; Molecular docking
• 刊名：Journal of Photochemistry and Photobiology A: Chemistry
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：336
• 期：Complete
• 页码：32-41
• 全文大小：1407 K
• 卷排序：336

文摘

There is an association BSA/PF in the ground state and FRET can occur. Binding is moderate and there is just one main binding site for PF in albumin. Binding does not perturb significantly the secondary structure of the albumin. Theoretical methods suggest Trp-212-containing binding site as the main binding site.