Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

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• 作者：Gina M. Calabrese¹ ; Larry D. Mesner¹ ; Joseph P. Stains² ; Steven M. Tommasini³ ; Mark C. Horowitz³ ; Clifford J. Rosen⁴ ; Charles R. Farber¹ ; ⁵ ; ⁶ ; ^{crf2s@virginia.edu}
• 关键词：bone mineral density ; BMD ; osteoporosis ; fracture ; bone fragility ; genetics ; co-expression network ; systems genetics ; genome-wide association study ; GWAS
• 刊名：Cell Systems
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：4
• 期：1
• 页码：46-59.e4
• 全文大小：3878 K
• 卷排序：4

文摘

Integrating GWAS and networks can predict causal GWAS genes BMD GWAS data and a bone network identified the Osteoblast Functional Module (OFM) The OFM was used to predict causal genes for 30 of 64 BMD GWAS loci Predicted genes, SPTBN1 and MARK3, regulate BMD and are potential casual GWAS genes