In vitro investigation of ultrasound-induced oxidative stress on human lens epithelial cells

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• 作者：Patrick Rwei^a ; ¹ ; Cihun-Siyong Alex Gong^a ; ^b ; ^c ; ¹ ; Li-Jyuan Luo^d ; Meng-Bo Lin^a ; Jui-Yang Lai^c ; ^e ; ^{jylai@mail.cgu.edu.tw} ; Hao-Li Liu^a ; ^f ; ^{haoliliu@mail.cgu.edu.tw}
• 关键词：Ultrasound ; Microbubble ; Calcium ion ; HLE-B3 ; Oxidative stress ; Reactive oxygen species
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：954-960
• 全文大小：1757 K
• 卷排序：482

文摘

An oxidative stress model of human lens epithelial cells was induced by ultrasound. Addition of microbubbles enhanced ultrasound cavitation and shear stress effect. Ultrasound-mediated microbubble technique was found to induce ROS in HLE-B3 cells. Generating oxidative stress could be controlled by ultrasound exposure conditions.