ar0005">Modifying action of nicotine and acetylcholine at low concentrations on N-formyl-MLF-induced ROS production and adhesion of neutrophils from inflammatory site of mice was demonstrated.
ar0010">Antagonists of nicotinic acetylcholine receptors (nAChRs) eliminated agonist effects. Nicotine induced Ca2+-spiking activity which was prevented by nAChR antagonist. RT-PCR analysis revealed the expression of mRNAs encoding α2, α3, α4, α5, α6, α7, α9, β2, β3, and β4 nAChR subunits.
ar0015">The data suggest involvement of nAChRs of α7 and possibly α3β2 or α6* subtypes in regulation of specific neutrophil functions.